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List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreductases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 1.1 Acting on the CH-OH group of donors

EC 1.1.1 With Nicotinamide adenine dinucleotide or NADP as acceptor

EC 1.1.2 With a cytochrome as acceptor

EC 1.1.3 With oxygen as acceptor

EC 1.1.4 With a disulfide as acceptor

  • EC 1.1.4.1: Now EC 1.17.4.4, vitamin-K-epoxide reductase (warfarin-sensitive)
  • EC 1.1.4.2: Now EC 1.17.4.5, vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor

EC 1.1.9 With a copper protein as acceptor

EC 1.1.98 With other, known, acceptors

EC 1.1.99 With unknown physiological acceptors

EC 1.2 Acting on the aldehyde or oxo group of donors

EC 1.2.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.2.2 With a cytochrome as acceptor

  • : formate dehydrogenase (cytochrome)
  • EC 1.2.2.2: Now covered by EC 1.2.5.1, pyruvate dehydrogenase (quinone)
  • EC 1.2.2.3: Now EC 1.17.2.3, formate dehydrogenase (cytochrome-c-553)
  • EC 1.2.2.4: Now classified as EC 1.2.5.3, aerobic carbon monoxide dehydrogenase

EC 1.2.3 With oxygen as acceptor

EC 1.2.4 With a disulfide as acceptor

EC 1.2.5 With a quinone or similar compound as acceptor

EC 1.2.7 With an iron–sulfur protein as acceptor

EC 1.2.98: With other, known physiological acceptors

EC 1.2.99: With unknown physiological acceptors

EC 1.3 Acting on the CH-CH group of donors

EC 1.3.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.3.2 With a cytochrome as acceptor

EC 1.3.3 With oxygen as acceptor

EC 1.3.5 With a quinone or related compound as acceptor

EC 1.3.7 With an iron–sulfur protein as acceptor

EC 1.3.8 With a flavin as acceptor

EC 1.3.98 With other,known physiological acceptors

EC 1.3.99 With unknown physiological acceptors

EC 1.4 Acting on the CH-NH<sub>2</sub> group of donors

EC 1.4.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.4.2 With a cytochrome as acceptor

EC 1.4.3 With oxygen as acceptor

EC 1.4.4 With a disulfide as acceptor

EC 1.4.5 With a quinone or other compound as acceptor

EC 1.4.7 With an iron–sulfur protein as acceptor

EC 1.4.9 With a copper protein as acceptor

EC 1.4.98 With other, known physiological acceptors

EC 1.4.99 With unknown physiological acceptors

EC 1.5 Acting on the CH-NH group of donors

EC 1.5.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.5.3 With oxygen as acceptor

EC 1.5.4 With a disulfide as acceptor

EC 1.5.5 With a quinone or similar compound as acceptor

EC 1.5.7 With an iron–sulfur protein as acceptor

EC 1.5.8 With a flavin or flavoprotein as acceptor

EC 1.5.98 With other, known, physiological acceptors

EC 1.5.99 With unknown physiological acceptors

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD or NADP as acceptor

EC 1.6.2 With a heme protein as acceptor

EC 1.6.3 With oxygen as acceptor

EC 1.6.4 With a disulfide as acceptor (deleted sub-class)

  • EC 1.6.4.1: now cystine reductase
  • EC 1.6.4.2: now glutathione-disulfide reductase
  • EC 1.6.4.3: now dihydrolipoyl dehydrogenase
  • EC 1.6.4.4: now protein-disulfide reductase
  • EC 1.6.4.5: now thioredoxin-disulfide reductase
  • EC 1.6.4.6: now CoA-glutathione reductase
  • EC 1.6.4.7: now asparagusate reductase
  • EC 1.6.4.8: now trypanothione-disulfide reductase
  • EC 1.6.4.9: now bis-γ-glutamylcystine reductase
  • EC 1.6.4.10: now CoA-disulfide reductase

EC 1.6.5 With a quinone or similar compound as acceptor

EC 1.6.6 With a nitrogenous group as acceptor

  • EC 1.6.6.1: Now , nitrate reductase (NADH)
  • EC 1.6.6.2: Now , nitrate reductase [NAD(P)H]
  • EC 1.6.6.3: Now , nitrate reductase (NADPH)
  • EC 1.6.6.4: Now , nitrite reductase [NAD(P)H]
  • EC 1.6.6.5: Now , nitrite reductase (NO-forming)
  • EC 1.6.6.6: Now , hyponitrite reductase
  • EC 1.6.6.7: Now , azobenzene reductase
  • EC 1.6.6.8: Now , GMP reductase
  • EC 1.6.6.9: Now known to be catalysed by , trimethylamine-N-oxide reductase
  • EC 1.6.6.10: Now , nitroquinoline-N-oxide reductase]
  • EC 1.6.6.11: Now , hydroxylamine reductase (NADH)
  • EC 1.6.6.12: Now , 4-(dimethylamino)phenylazoxybenzene reductase
  • EC 1.6.6.13: Now , N-hydroxy-2-acetamidofluorene reductase

EC 1.6.7 With an iron–sulfur protein as acceptor (deleted sub-subclass)

  • EC 1.6.7.1: now ferredoxin—NADP<sup>+</sup> reductase
  • EC 1.6.7.2: now rubredoxin—NAD<sup>+</sup> reductase
  • EC 1.6.7.3: now ferredoxin—NAD<sup>+</sup> reductase

EC 1.6.8 With a flavin as acceptor (deleted sub-subclass)

  • EC 1.6.8.1: Now FMN reductase
  • EC 1.6.8.2: Now flavin reductase

EC 1.6.99 With unknown physiological acceptors

  • : NADPH dehydrogenase
  • EC 1.6.99.2: Now , NAD(P)H dehydrogenase (quinone
  • EC 1.6.99.3: The activity is covered by ,
  • EC 1.6.99.4: Now , ferredoxin—NADP<sup>+</sup> reductase
  • EC 1.6.99.5: Now , NADH dehydrogenase (quinone)
  • EC 1.6.99.6: Now , NADPH dehydrogenase (quinone)
  • EC 1.6.99.7: Now , 6,7-dihydropteridine reductase
  • EC 1.6.99.8: Deleted
  • EC 1.6.99.9: Now , cob(II)alamin reductase
  • EC 1.6.99.10: included in , 6,7-dihydropteridine reductase
  • EC 1.6.99.11: Deleted
  • EC 1.6.99.12: Now , cyanocobalamin reductase (cyanide-eliminating)
  • EC 1.6.99.13: Now , ferric-chelate reductase

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.7.2 With a cytochrome as acceptor

EC 1.7.3 With oxygen as acceptor

EC 1.7.5 With a quinone or similar compound as acceptor

EC 1.7.6 With a nitrogenous group as acceptor

EC 1.7.7 With an iron–sulfur protein as acceptor

EC 1.7.99 With other acceptors

  • : hydroxylamine reductase
  • EC 1.7.99.2: deleted: reaction may have been due to the combined action of nitrous-oxide reductase and nitric-oxide reductase
  • EC 1.7.99.3: Now included with , nitrite reductase (NO-forming)
  • EC 1.7.99.4: Now , nitrate reductase (NADH), , nitrate reductase [NAD(P)H], , nitrate reductase (NADPH), , nitrate reductase (quinone), , nitrate reductase (ferredoxin) and , nitrate reductase (cytochrome)
  • EC 1.7.99.5: Now included with , methylenetetrahydrofolate reductase [NAD(P)H]
  • EC 1.7.99.6: Now nitrous-oxide reductase
  • EC 1.7.99.7: Now nitric oxide reductase (cytochrome c)
  • : hydroxylamine oxidoreductase
  • EC 1.7.99.8: Now classified as , hydrazine dehydrogenase

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.8.2 With a cytochrome as acceptor

EC 1.8.3 With oxygen as acceptor

EC 1.8.4 With a disulfide as acceptor

EC 1.8.5 With a quinone or similar compound as acceptor

EC 1.8.6 With a nitrogenous group as acceptor (deleted sub-subclass)

  • : Now included with glutathione transferase

EC 1.8.7 With an iron–sulfur protein as acceptor

EC 1.8.98 With other, known, acceptors

EC 1.8.99 With other acceptors

EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

  • EC 1.9.3.1: Now , cytochrome-c oxidase
  • EC 1.9.3.2: Now included with , nitrite reductase (NO-forming)

EC 1.9.6 With a nitrogenous group as acceptor

EC 1.9.98 With other, known, physiological acceptors

EC 1.9.99 With other acceptors

  • EC 1.9.99.1: Now , iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.10.2 With a cytochrome as acceptor

EC 1.10.3 With oxygen as acceptor

EC 1.10.5 With a quinone or related compound as acceptor

EC 1.10.9 With a copper protein as acceptor

  • EC 1.10.9.1: Now , plastoquinol—plastocyanin reductase

EC 1.10.99 With unknown physiological acceptors

  • EC 1.10.99.1: Now plastoquinol—plastocyanin reductase
  • EC 1.10.99.2: Now ribosyldihydronicotinamide dehydrogenase (quinone)
  • EC 1.10.99.3: Now violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

EC 1.11.2 Peroxygenase

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.12.2 With a cytochrome as acceptor

EC 1.12.5 With a quinone or similar compound as acceptor

  • :

EC 1.12.7 With an iron–sulfur protein as acceptor

EC 1.12.98 With other known acceptors

EC 1.12.99 With unknown physiological acceptors

  • EC 1.12.99.1: Now , coenzyme F<sub>420</sub> hydrogenase
  • EC 1.12.99.2: Now shown to be two enzymes, , Methanosarcina-phenazine hydrogenase and , CoB—CoM heterodisulfide reductase
  • EC 1.12.99.3: Now , hydrogen:quinone oxidoreductase
  • EC 1.12.99.4: Now , 5,10-methenyltetrahydromethanopterin hydrogenase
  • EC 1.12.99.5: Identical to , 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
  • : hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.11 With incorporation of two atoms of oxygen

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

EC 1.13.99 Miscellaneous

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

  • EC 1.14.1.1: now , unspecific monooxygenase
  • EC 1.14.1.2: now , kynurenine 3-monooxygenase
  • EC 1.14.1.3: deleted, covered by , squalene monooxygenase and , lanosterol synthase
  • EC 1.14.1.4: now , kynurenine 7,8-hydroxylase
  • EC 1.14.1.5: now ; imidazoleacetate 4-monooxygenase
  • EC 1.14.1.6: now , steroid 11β-monooxygenase
  • EC 1.14.1.7: now , steroid 17α-monooxygenase
  • EC 1.14.1.8: now , steroid 21-monooxygenase
  • EC 1.14.1.9: deleted
  • EC 1.14.1.10: now estradiol 6β-monooxygenase
  • EC 1.14.1.11: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

  • EC 1.14.2.1: now , dopamine β-monooxygenase
  • EC 1.14.2.2: now , 4-hydroxyphenylpyruvate dioxygenase

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

  • EC 1.14.3.1: now , phenylalanine 4-monooxygenase

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

EC 1.14.15 With reduced iron–sulfur protein as one donor, and incorporation of one atom of oxygen

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen into the other donor

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of O<sub>2</sub> to two molecules of water

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

  • EC 1.14.21.1: Now , (S)-stylopine synthase
  • EC 1.14.21.2: Now , (S)-cheilanthifoline synthase
  • EC 1.14.21.3: Now , berbamunine synthase
  • EC 1.14.21.4: Now , salutaridine synthase
  • EC 1.14.21.5: Now , (S)-canadine synthase
  • EC 1.14.21.6: Now , Δ<sup>7</sup>-sterol 5(6)-desaturase
  • EC 1.14.21.7: Now , biflaviolin synthase
  • EC 1.14.21.8: Now , pseudobaptigenin synthase
  • EC 1.14.21.9: Now , mycocyclosin synthase *
  • EC 1.14.21.10: Now , fumitremorgin C synthase *
  • EC 1.14.21.11: Now , (–)-pluviatolide synthase *
  • EC 1.14.21.12: Now , (S)-nandinine synthase *

EC 1.14.99 Miscellaneous

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.16.3 With oxygen as acceptor

EC 1.16.5 With a quinone or similar compound as acceptor

  • EC 1.16.5.1: Now , ascorbate ferrireductase (transmembrane)

EC 1.16.8 With a flavin as acceptor

  • EC 1.16.8.1: activity now known to be catalyzed by , corrinoid adenosyltransferase

EC 1.16.9 With a copper protein as acceptor

  • :

EC 1.16.98 With other, known, physiological acceptors

  • EC 1.16.98.1: Now iron:rusticyanin reductase

EC 1.16.99 With unknown physiological acceptors

EC 1.17 Acting on CH or CH<sub>2</sub> groups

EC 1.17.1 With NAD or NADP as acceptor

EC 1.17.2 With a cytochrome as acceptor

EC 1.17.3 With oxygen as acceptor

EC 1.17.4 With a disulfide as acceptor

EC 1.17.5 With a quinone or similar compound as acceptor

EC 1.17.7 With an iron–sulfur protein as acceptor

EC 1.17.98 With other, known, physiological acceptors

EC 1.17.99 With unknown physiological acceptors

EC 1.18 Acting on iron–sulfur proteins as donors

EC 1.18.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.18.2 With dinitrogen as acceptor (deleted sub-subclass)

  • EC 1.18.2.1: now , nitrogenase

EC 1.18.3 With H<sup>+</sup> as acceptor (deleted sub-subclass)

  • EC 1.18.3.1: Now , ferredoxin hydrogenase

EC 1.18.6 With dinitrogen as acceptor

EC 1.18.96 With other, known, acceptors (deleted sub-subclass)

  • EC 1.18.96.1: Now , superoxide reductase

EC 1.18.99 With H<sup>+</sup> as acceptor (deleted sub-subclass)

  • EC 1.18.99.1: Now , ferredoxin hydrogenase

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

EC 1.19.6 With dinitrogen as acceptor

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD<sup>+</sup> as acceptor

EC 1.20.2 Acting on phosphorus or arsenic in donors, with NAD(P)<sup>+</sup> as acceptor

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

EC 1.20.9 With a copper protein as acceptor

EC 1.20.98 With other, known acceptors

  • EC 1.20.98.1: Now , arsenate reductase (azurin)

EC 1.20.99 With unknown physiological acceptors

EC 1.21 Catalysing the reaction X-H + Y-H = X-Y

EC 1.21.3 With oxygen as acceptor

EC 1.21.4 With a disulfide as acceptor

EC 1.21.98 With other, known, physiological acceptors

EC 1.21.99 With unknown physiological acceptors

EC 1.22 Acting on halogen in donors

EC 1.22.1 With NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor

  • EC 1.22.1.1: Now , iodotyrosine deiodinase

EC 1.23 Reducing C-O-C group as acceptor

EC 1.23.1 With NADH or NADPH as donor

EC 1.97 Other oxidoreductases

EC 1.97.1 Sole sub-subclass for oxidoreductases that do not belong in the other subclasses

EC 1.98 Enzymes using H<sub>2</sub> as reductant (deleted subclass)

EC 1.98.1.1: Now , ferredoxin hydrogenase

EC 1.99 Other enzymes using O<sub>2</sub> as oxidant

EC 1.99.1 Hydroxylases (now covered by EC 1.14)

  • EC 1.99.1.1: deleted, Now , ferredoxin hydrogenase
  • EC 1.99.1.2: deleted, Now , phenylalanine 4-monooxygenase
  • EC 1.99.1.3: deleted, nicotinate 6-hydroxylase
  • EC 1.99.1.4: deleted, tryptophan 5-hydroxylase
  • EC 1.99.1.5: deleted, Now , kynurenine 3-monooxygenase
  • EC 1.99.1.6: deleted, steroid 11α-hydroxylase
  • EC 1.99.1.7: deleted, Now , steroid 11β-monooxygenase
  • EC 1.99.1.8: deleted, steroid 6β-hydroxylase
  • EC 1.99.1.9: deleted, Now , steroid 17α-monooxygenase
  • EC 1.99.1.10: deleted, steroid 19-hydroxylase
  • EC 1.99.1.11: deleted, Now , steroid 21-monooxygenase
  • EC 1.99.1.12: deleted, alkoxyaryl hydroxylase
  • EC 1.99.1.13: deleted, covered by (squalene monooxygenase) and by (lanosterol synthase)
  • EC 1.99.1.14: deleted, Now , 4-hydroxyphenylpyruvate dioxygenase

EC 1.99.2 Oxygenases (now covered by EC 1.13)

  • EC 1.99.2.1: deleted, now , lipoxygenase
  • EC 1.99.2.2: deleted, now , catechol 1,2-dioxygenase
  • EC 1.99.2.3: deleted, now , protocatechuate 3,4-dioxygenase
  • EC 1.99.2.4: deleted, now , gentisate 1,2-dioxygenase
  • EC 1.99.2.5: deleted, now , homogentisate 1,2-dioxygenase
  • EC 1.99.2.6: deleted, now , inositol oxygenase

References