2-dehydropantoate 2-reductase

In enzymology, 2-dehydropantoate 2-reductase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (R)-pantoic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are ketopantoic acid, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP⁺ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes , , , , and .

References