In enzymology, a vomilenine reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are 1,2-dihydrovomilenine and NADP<sup>+</sup>, whereas its 3 products are vomilenine, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydrovomilenine:NADP+ oxidoreductase. This enzyme participates in indole and ipecac alkaloid biosynthesis.