L-aminoadipate-semialdehyde dehydrogenase

In enzymology, a L-aminoadipate-semialdehyde dehydrogenase () is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are L-2-aminoadipate 6-semialdehyde (L-allysine), oxidised nicotinamide adenine dinucleotide (NAD⁺), and water. Its products are (S)-α-aminoadipic acid, reduced NADH, and a proton. This enzyme can also use nicotinamide adenine dinucleotide phosphate as its cofactor.

The enzyme participates in lysine biosynthesis and biodegradation.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include:

• aminoadipate semialdehyde dehydrogenase,
• 2-aminoadipate semialdehyde dehydrogenase,
• alpha-aminoadipate-semialdehyde dehydrogenase,
• alpha-aminoadipate reductase,
• 2-aminoadipic semialdehyde dehydrogenase,
• L-alpha-aminoadipate delta-semialdehyde oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase,
• L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine,
• and dinucleotide oxidoreductase.

References