Tryptophan N-monooxygenase (, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating). This enzyme catalyses the following chemical reaction
L-tryptophan + 2 O<sub>2</sub> + 2 NADPH + 2 H<sup>+</sup> (E)-indol-3-ylacetaldoxime + 2 NADP<sup>+</sup> + CO<sub>2</sub> + 3 H<sub>2</sub>O (overall reaction)
(1a) L-tryptophan + O<sub>2</sub> + NADPH + H<sup>+</sup> N-hydroxy-L-tryptophan + NADP<sup>+</sup> + H<sub>2</sub>O
(1b) N-hydroxy-L-tryptophan + O<sub>2</sub> + NADPH + H<sup>+</sup> N,N-dihydroxy-L-tryptophan + NADP<sup>+</sup> + H<sub>2</sub>O
(1c) N,N-dihydroxy-L-tryptophan (E)-indol-3-ylacetaldoxime + CO<sub>2</sub> + H<sub>2</sub>O
Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).
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