Sulfopropanediol 3-dehydrogenase (, DHPS 3-dehydrogenase (sulfolactate forming), 2,3-dihydroxypropane-1-sulfonate 3-dehydrogenase (sulfolactate forming), dihydroxypropanesulfonate 3-dehydrogenase, hpsN (gene)) is an enzyme with systematic name (R)-2,3-dihydroxypropane-1-sulfonate:NAD<sup>+</sup> 3-oxidoreductase. This enzyme catalyses the following chemical reaction:
The enzyme is involved in degradation of (R)-2,3-dihydroxypropanesulfonate.