In enzymology, 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 1,5-anhydro-D-mannitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP). Its products are 1,5-anhydro-D-fructose, reduced NADPH, and a proton.
This enzyme belongs to the common family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-mannitol:NADP oxidoreductase. Other names in common use include 1,5-anhydro-D-fructose reductase (ambiguous), and AFR.