Acrylyl-CoA reductase (NADPH) () is an enzyme with systematic name propanoyl-CoA:NADP<sup>+</sup> oxidoreductase. This enzyme catalyses the following chemical reaction
This enzyme catalyses a step in the 3-hydroxypropionate/4-hydroxybutyrate cycle, an autotrophic CO<sub>2</sub> fixation pathway found in some Thermoacidophilic archaea.