In enzymology, a L-glycol dehydrogenase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are L-glycol, NAD<sup>+</sup>, and NADP<sup>+</sup>, whereas its 4 products are 2-hydroxycarbonyl compound, NADH, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is L-glycol:NAD(P)<sup>+</sup> oxidoreductase. Other names in common use include glycol (nicotinamide adenine dinucleotide (phosphate)), dehydrogenase, L-(+)-glycol:NAD(P)<sup>+</sup> oxidoreductase, and L-glycol:NAD(P)<sup>+</sup> dehydrogenase.