D-malate dehydrogenase (decarboxylating)

In enzymology, D-malate dehydrogenase (decarboxylating) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are D-malic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are pyruvic acid, carbon dioxide, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of a donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-malate:NAD⁺ oxidoreductase (decarboxylating). Other names in common use include D-malate dehydrogenase, D-malic enzyme, bifunctional L(+)-tartrate dehydrogenase-D(+)-malate (decarboxylating). This enzyme participates in butanoate metabolism.

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