-Sorbose 1-dehydrogenase (, SDH) is an enzyme with systematic name -sorbose:acceptor 1-oxidoreductase. This enzyme catalyses the following chemical reaction:
The product, -sorbosone, is an intermediate in bacterial 2-keto-L-gulonic-acid formation. Co<sup>2+</sup> stimulates activity of this membrane-bound enzyme, while Cu<sup>2+</sup> acts as an inhibitor.