3-dehydroquinate synthase II (, DHQ synthase II, MJ1249 (gene), aroB' (gene)) is an enzyme with systematic name 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD<sup>+</sup> oxidoreductase (deaminating). This enzyme catalyses the following chemical reaction
The three substrates of this enzyme are 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonic acid (1), water, and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 3-dehydroquinic acid, ammonia, reduced NADH, and a proton. It was isolated from the archaeon Methanocaldococcus jannaschii.