In enzymology, a 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 2-dehydro-3-deoxy-D-gluconic acid and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-gluconate:NADP<sup>+</sup> 6-oxidoreductase. Other names in common use include 2-keto-3-deoxy-D-gluconate dehydrogenase, and 2-keto-3-deoxygluconate dehydrogenase.