Pyridoxal 4-dehydrogenase

In enzymology, pyridoxal 4-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are pyridoxal and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 4-pyridoxolactone, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is pyridoxal:NAD⁺ 4-oxidoreductase. This enzyme is also called pyridoxal dehydrogenase. This enzyme participates in vitamin B₆ metabolism.

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