In enzymology, quinate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of the enzyme are L-quinic acid and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 3-dehydroquinic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is L-quinate:NAD<sup>+</sup> 3-oxidoreductase. Other names in common use include quinic dehydrogenase, quinate:NAD oxidoreductase, quinate 5-dehydrogenase, and quinate:NAD<sup>+</sup> 5-oxidoreductase. This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.