In enzymology, 4-(hydroxymethyl)benzenesulfonate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 4-(hydroxymethyl)benzenesulfonic acid and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 4-formylbenzenesulfonic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 4-(hydroxymethyl)benzenesulfonate:NAD<sup>+</sup> oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.