In enzymology, strombine dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are strombine, oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>), and water. Its products are glycine, reduced NADH, pyruvic acid, and a proton. Strombine, also known as (N-(carboxymethyl)-D-alanine), is a member of the class of compounds called opines.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-(carboxymethyl)-D-alanine:NAD+ oxidoreductase (glycine-forming). Other names in common use include strombine[N-(carboxymethyl)-D-alanine]dehydrogenase, and N-(carboxymethyl)-D-alanine: NAD+ oxidoreductase.