15-hydroxyprostaglandin-D dehydrogenase (NADP+)

In enzymology, 15-hydroxyprostaglandin-D dehydrogenase (NADP⁺) () is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are prostaglandin D₂ and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are 15-dehydro-prostaglandin D₂, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate:NADP⁺ 15-oxidoreductase. Other names in common use include prostaglandin-D 15-dehydrogenase (NADP⁺), dehydrogenase, prostaglandin D2, NADP⁺-PGD2 dehydrogenase, dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine, dinucleotide phosphate), 15-hydroxy PGD2 dehydrogenase, 15-hydroxyprostaglandin dehydrogenase (NADP⁺), NADP⁺-dependent 15-hydroxyprostaglandin dehydrogenase, prostaglandin D2 dehydrogenase, NADP⁺-linked 15-hydroxyprostaglandin dehydrogenase, NADP⁺-specific 15-hydroxyprostaglandin dehydrogenase, NADP⁺-linked prostaglandin D2 dehydrogenase, and 15-hydroxyprostaglandin-D dehydrogenase (NADP⁺). This enzyme participates in arachidonic acid metabolism.

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