In enzymology, sorbose reductase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-sorbitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are L-sorbose (shown in open-chain keto form), reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-glucitol:NADP<sup>+</sup> oxidoreductase. This enzyme is also called Sou1p.