In enzymology, cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthalene and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are 1,2-naphthalenediol, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase. Other names in common use include (+)-cis-naphthalene dihydrodiol dehydrogenase, naphthalene dihydrodiol dehydrogenase, and cis-dihydrodiol naphthalene dehydrogenase. This enzyme participates in 1- and 2-methylnaphthalene degradation and naphthalene and anthracene degradation.