In enzymology, acylglycerone-phosphate reductase () is an enzyme that catalyzes the chemical reaction
The substrate of this enzyme is an ester of the long-chain fatty acid, (palmitic acid), which reacts with oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). This converts the hydroxy group of the glycerol fragment to the corresponding ketone. The cofactor is converted to NADPH, and a proton is released.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP<sup>+</sup> oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.