In enzymology, carbon-monoxide dehydrogenase (ferredoxin) () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are carbon monoxide, water, and oxidized ferredoxin. Its products are carbon dioxide and reduced ferredoxin.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is carbon-monoxide,water:ferredoxin oxidoreductase.