In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, NAD<sup>+</sup>, and H<sub>2</sub>O, whereas its 3 products are UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate, NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:NAD<sup>+</sup> 6-oxidoreductase. Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzyme participates in aminosugars metabolism.