2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent) (, (gene)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase. This enzyme catalyses the following chemical reaction
This enzyme participates in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family.