In enzymology, 1,5-anhydro-D-fructose reductase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 1,5-anhydroglucitol and oxidised nicotinamide adenine dinucleotide phosphate (NADP). Its products are 1,5-anhydro-D-fructose, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD or NADP as acceptor. The systematic name of this enzyme class is 1,5-anhydro-D-glucitol:NADP oxidoreductase.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .