Tetrahydroxynaphthalene reductase

In enzymology, tetrahydroxynaphthalene reductase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are scytalone and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are naphthalene-1,3,6,8-tetrol, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is scytalone:NADP⁺ Delta5-oxidoreductase.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

References