2-oxopropyl-CoM reductase (carboxylating) () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 2-mercaptoethanesulfonic acid (Coenzyme M), acetoacetic acid, and nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are 2-acetylthioethanesulfonic acid (2-oxopropyl-Coenzyme M), carbon dioxide, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-mercaptoethanesulfonate, acetoacetate:NADP+ oxidoreductase (decarboxylating). Other names in common use include NADPH:2-(2-ketopropylthio)ethanesulfonate, oxidoreductase/carboxylase, and NADPH:2-ketopropyl-coenzyme M oxidoreductase/carboxylase.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .