In enzymology, a galactose 1-dehydrogenase (NADP<sup>+</sup>) () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are D-galactose (shown in its aldehydo form) and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are -galactono-1,5-lactone, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-galactose:NADP<sup>+</sup> 1-oxidoreductase. Other names in common use include D-galactose dehydrogenase (NADP<sup>+</sup>), and galactose 1-dehydrogenase (NADP<sup>+</sup>). This enzyme participates in galactose metabolism.