In enzymology, 6-oxohexanoate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 6-oxohexanoic acid, oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>), and water. Its products are adipic acid, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 6-oxohexanoate:NADP+ oxidoreductase. This enzyme is involved in cyclohexanol degradation in Acinetobacter.