Glucose 1-dehydrogenase

In enzymology, glucose 1-dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are β-D-glucose and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are D-glucono-1,5-lactone, reduced NADH, and a proton. The enzyme can alternatively use nicotinamide adenine dinucleotide phosphate (NADP⁺) for oxidation and in that case produces NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)⁺ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)⁺).

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , and .

References