21-hydroxysteroid dehydrogenase (NADP+)

In enzymology, 21-hydroxysteroid dehydrogenase (NADP⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (5β)-pregnan-21-ol and oxidised nicotinamide adenine dinucleotide phosphate (NADP⁺). Its products are (5β)-pregnan-21-al, reduced NADPH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NADP⁺ 21-oxidoreductase. Other names in common use include 21-hydroxy steroid dehydrogenase, 21-hydroxy steroid (nicotinamide adenine dinucleotide phosphate), dehydrogenase, 21-hydroxy steroid dehydrogenase (nicotinamide adenine dinucleotide, phosphate), NADP⁺-21-hydroxysteroid dehydrogenase, and 21-hydroxysteroid dehydrogenase (NADP⁺).

See also

• 21-hydroxysteroid dehydrogenase (NAD+), an enzyme which catalyses the same reaction but using an alternative cofactor

References