21-hydroxysteroid dehydrogenase (NAD+)

In enzymology, 21-hydroxysteroid dehydrogenase (NAD⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (5β)-pregnan-21-ol and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are (5β)-pregnan-21-al, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 21-hydroxysteroid:NAD⁺ 21-oxidoreductase. This enzyme is also called 21-hydroxysteroid dehydrogenase (NAD⁺).

See also

• 21-hydroxysteroid dehydrogenase (NADP+), an enzyme which catalyses the same reaction but using an alternative cofactor

References