In enzymology, tryptophan alpha,beta-oxidase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are L-tryptophan and oxygen. Its products are ñ,ò-didehydrotryptophan and hydrogen peroxide.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is L-tryptophan:oxygen alpha,beta-oxidoreductase. Other names in common use include L-tryptophan 2',3'-oxidase, and L-tryptophan alpha,beta-dehydrogenase. It employs one cofactor, heme.