In enzymology, a D-arabinitol 4-dehydrogenase () is an enzyme that catalyzes the chemical reaction
Its two substrates are D-arabinitol and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). The products are D-xylulose, reduced cofactor NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is D-arabinitol:NAD<sup>+</sup> 4-oxidoreductase. Other names in common use include D-arabitol dehydrogenase and arabitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.