5β-Reductase

5β-Reductase, or Δ⁴-3-oxosteroid 5β-reductase (, 3-oxo-Δ⁴-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ⁴-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ⁴-3-ketosteroid 5β-reductase, Δ⁴-5β-reductase, Δ⁴-hydrogenase, 4,5β-dihydrocortisone:NADP⁺ Δ⁴-oxidoreductase, 3-oxo-5β-steroid:NADP⁺ Δ⁴-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP⁺ 4,5-oxidoreductase.

This enzyme catalyses the following general chemical reaction:

For example, it interconverts 5β-dihydrocortisone and cortisone:

The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to transform them into 5β-reduced metabolites. It can also act on aldosterone, corticosterone, and cortisol.

See also

• 5α-Reductase
• Steroidogenic enzyme

References

External links