In enzymology, a mevaldate reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are (R)-mevalonate and NAD<sup>+</sup>, whereas its 3 products are mevaldate, NADH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is (R)-mevalonate:NAD<sup>+</sup> oxidoreductase. This enzyme is also called mevalonic dehydrogenase.
In 2022, this entry was deleted from the Enzyme Classification, and is now included in with the entry for Alcohol dehydrogenase.