In enzymology, sorbose 5-dehydrogenase (NADP<sup>+</sup>) () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are L-sorbose and oxidised nicotinamide adenine dinucleotide phosphate (NADP<sup>+</sup>). Its products are 5-dehydro-D-fructose, reduced NADPH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is L-sorbose:NADP<sup>+</sup> 5-oxidoreductase. Other names in common use include 5-ketofructose reductase, 5-keto-D-fructose reductase, sorbose (nicotinamide adenine dinucleotide phosphate) dehydrogenase, reduced nicotinamide adenine dinucleotide phosphate-linked, reductase, and sorbose 5-dehydrogenase (NADP<sup>+</sup>).