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5β-Reductase

5β-Reductase, or Δ<sup>4</sup>-3-oxosteroid 5β-reductase (, 3-oxo-Δ<sup>4</sup>-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ<sup>4</sup>-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ<sup>4</sup>-3-ketosteroid 5β-reductase, Δ<sup>4</sup>-5β-reductase, Δ<sup>4</sup>-hydrogenase, 4,5β-dihydrocortisone:NADP<sup>+</sup> Δ<sup>4</sup>-oxidoreductase, 3-oxo-5β-steroid:NADP<sup>+</sup> Δ<sup>4</sup>-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP<sup>+</sup> 4,5-oxidoreductase.

This enzyme catalyses the following general chemical reaction:

5β-cholestan-3-one + NADP<sup>+</sup> cholest-4-en-3-one + NADPH + H<sup>+</sup>

For example, it interconverts 5β-dihydrocortisone and cortisone:

The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to transform them into 5β-reduced metabolites. It can also act on aldosterone, corticosterone, and cortisol.

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