Succinate-semialdehyde dehydrogenase (acylating) (, succinyl-coA reductase, coenzyme-A-dependent succinate-semialdehyde dehydrogenase) is an enzyme with systematic name succinate semialdehyde:NADP<sup>+</sup> oxidoreductase (CoA-acylating). This enzyme catalyses the following chemical reaction
The enzyme catalyses the NADPH-dependent reduction of succinyl-CoA to succinate semialdehyde.