In enzymology, meso-tartrate dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are meso-tartaric acid and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are dihydroxyfumaric acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is meso-tartrate:NAD+ oxidoreductase. This enzyme participates in glyoxylic acid and dicarboxylic acid metabolism.