3-Succinoylsemialdehyde-pyridine dehydrogenase () is an enzyme with systematic name 4-oxo-4-(pyridin-3-yl)butanal:NADP<sup>+</sup> oxidoreductase. This enzyme catalyses the following chemical reaction
The enzyme has been characterized from the soil bacterium Pseudomonas sp. HZN6, which degrades nicotine.