In enzymology, 3-hydroxycyclohexanone dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 3-hydroxycyclohexanone and an electron acceptor. Its products are 1,3-cyclohexanedione and the corresponding reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is 3-hydroxycyclohexanone:acceptor 1-oxidoreductase.