In enzymology, a progesterone 11alpha-monooxygenase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are progesterone, AH2, and O<sub>2</sub>, whereas its 3 products are 11alpha-hydroxyprogesterone, A, and H<sub>2</sub>O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is . This enzyme is also called . This enzyme participates in c21-steroid hormone metabolism.