Glucose 1-dehydrogenase (NAD+)

In enzymology, glucose 1-dehydrogenase (NAD⁺) () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are D-glucose and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are glucono-δ-lactone, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is D-glucose:NAD⁺ 1-oxidoreductase. Other names in common use include D-glucose:NAD⁺ oxidoreductase, D-aldohexose dehydrogenase, and glucose 1-dehydrogenase (NAD⁺).

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .

See also

• Glucose 1-dehydrogenase (NADP+) which catalyses the same reaction but uses an alternative cofactor.

References