p-benzoquinone reductase (NADPH) () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are p-benzoquinone. reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. Its products are hydroquinone and NADP<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NADPH:p-benzoquinone oxidoreductase. This enzyme participates in the metabolism of 4-nitrophenol in a Moraxella species of bacteria.