In enzymology, succinylglutamate-semialdehyde dehydrogenase () is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are N-succinyl-L-glutamic 5-semialdehyde, oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>), and water. Its products are N-succinyl-L-glutamic acid, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is N-succinyl-L-glutamate 5-semialdehyde:NAD+ oxidoreductase. Other names in common use include succinylglutamic semialdehyde dehydrogenase, N-succinylglutamate 5-semialdehyde dehydrogenase, SGSD, AruD, and AstD. This enzyme participates in arginine and proline metabolism.