Dimethylmalate dehydrogenase

In enzymology, dimethylmalate dehydrogenase () is an enzyme that catalyzes the chemical reaction

The two substrates of this enzyme are (R)-3,3-dimethylmalic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are α-ketoisovaleric acid, carbon dioxide, reduced NADH, and a proton.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3,3-dimethylmalate:NAD⁺ oxidoreductase (decarboxylating). This enzyme is also called beta,beta-dimethylmalate dehydrogenase. This enzyme participates in pantothenate and coa biosynthesis. It has 5 cofactors: ammonia, manganese, cobalt, potassium, and NH₄⁺.

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