In enzymology, a -iditol 2-dehydrogenase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are D-iditol and oxidised nicotinamide adenine dinucleotide (NAD<sup>+</sup>). Its products are D-sorbose, reduced NADH, and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is -iditol:NAD<sup>+</sup> 2-oxidoreductase. This enzyme is also called -sorbitol dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism.