3-dehydro-L-gulonate 2-dehydrogenase

In enzymology, 3-dehydro-L-gulonate 2-dehydrogenase () is an enzyme that catalyzes the chemical reaction:

The two substrates of this enzyme are 3-dehydro-L-gulonic acid and oxidised nicotinamide adenine dinucleotide (NAD⁺). Its products are 2,3-diketogulonic acid, reduced NADH, and a proton. The enzyme can also use the alternative cofactor, nicotinamide adenine dinucleotide phosphate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3-dehydro-L-gulonate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include 3-keto-L-gulonate dehydrogenase, 3-ketogulonate dehydrogenase, 3-keto-L-gulonate dehydrogenase, and 3-ketogulonate dehydrogenase. This enzyme participates in pentose and glucuronate interconversions and ascorbate and aldarate metabolism.

References