Delta8-fatty-acid desaturase (, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an enzyme with systematic name phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase. This enzyme catalyses the following chemical reaction
This enzyme, which has been found mainly in plants, introduces a double bond at Delta8 of C18 and C20 fatty acids.